For licensed healthcare professionals. The protocol figures below are drawn from published labeling and peer-reviewed literature for educational reference. They are not a prescription, not a recommendation, and not a substitute for the dispensing pharmacy's labeling or your own clinical judgment.
Longevity
Rapamycin
aka Sirolimus
FDA approved Not WADA-listed
mTOR inhibitor FDA-approved as an immunosuppressant; off-label longevity dosing typically intermittent low-dose oral.
At a glance
- Common vial size
- Not vial-based
- Reference dose
- 6 mg
- Frequency
- Once weekly, oral
Reference titration protocol
Oral 2 → 5 → 10 mg once weekly (PEARL trial dose range).
| Step | Dose | Duration | Administrations / week |
|---|---|---|---|
| 1 | 2 mg | 4 weeks | 1× |
| 2 | 5 mg | 4 weeks | 1× |
| 3 | 8 mg | 4 weeks | 1× |
Clinical notes
- Off-label longevity use — periodic lipid, glucose, and CBC monitoring
References
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Also in Longevity
NAD+
Coenzyme central to redox metabolism and sirtuin signaling. Compounded injectable form used off-label for energy/longevity.
Epithalon
Tetrapeptide studied in Russian gerontology for telomerase activation and pineal regulation. Human data limited to small studies.
Humanin
Mitochondrial-derived peptide implicated in cytoprotection, insulin sensitivity, and neuronal survival. Early-stage research.
DSIP
Nonapeptide studied for sleep architecture, stress modulation, and pain. Limited modern human trial data.
Glutathione
Major endogenous antioxidant tripeptide. Compounded injectable and IV forms often paired with NAD+ protocols.